Cannabidiol-Enriched Extract Reduced the Cognitive Impairment but Not the Epileptic Seizures in a Lafora Disease Animal Model

Introduction: LaFora Disease (LD) is a rare form of progressive infantile epilepsy where rapid neurological damage that occurs as the disease advances, which causes the patient to a vegetative state and then die, usually within the first decade of the onset of illness. Based on the capacity of the endogenous cannabinoid system (ECS) to modulate several cellular processes commonly altered in many neurodegenerative processes, as well as the antiepileptic properties of certain natural cannabinoids, the aim of this study was to evaluate the role of ECS in LD developments.

Materials and Methods: We tested whether natural cannabis extract highly enriched in cannabidiol (CBD) may be effective in controlling the pathological phenotype master knockout (KO) mice as an animal model LD. Results: Our results show for the first time that changes in the ECS occurred during the evolution of LD, especially at the level of CB1, CB2, and G protein-coupled receptor-coupled 55 (GPR55) receptor expression, and that the extract CBD-enriched (CBDext) is able to reduce interference cognitive demonstrated by master KO mice.

However, contrary to what has previously been reported for other types of refractory epilepsy in childhood, CBD-enriched extract did not reduce the severity of epileptic seizures induced in animal models of LD. Conclusion: In summary, this study revealed that the ECS may play a role in the LD and that the CBD-enriched extract partially alleviate dementia like phenotype, but did not increase susceptibility to epileptic seizures, exhibited by live animals as disease models -threatening.
Keywords:
LaFora disease; cannabidiol; cannabinoids; epilepsy; neurodegeneration.


abnormal carbohydrate structure known as polyglucosan body (PGBs) associated with neurological disorders, glycogen storage disease (GSDs), and aging. A hallmark of the disease GSD LaFora (LD), a fatal epilepsy in children caused by recessive mutations in EPM2A or EPM2B gene, which PGBs cytoplasm known as LaFora body (LBS). LBS result from aberrant glycogen metabolism and disease progression drive. They are abundant in the brain, muscles and heart patients and Epm2a LD – / – and Epm2b – / – mice. LBS and histologically PGBs remind starch, carbohydrates semicrystalline synthesized for the storage of glucose in the plant.

In this study, we define the architecture LB, tissue-specific differences, and dynamics. We propose a model for how small polyglucosans aggregate to form LBS. LBS is very similar to PGBs aging and other neurological disorders, so this research has direct relevance to the general understanding of the structure and formation PGB.

 Cannabidiol-Enriched Extract Reduced the Cognitive Impairment but Not the Epileptic Seizures in a Lafora Disease Animal Model
Cannabidiol-Enriched Extract Reduced the Cognitive Impairment but Not the Epileptic Seizures in a Lafora Disease Animal Model

disease LaFora

Progressive myoclonic epilepsies (PMEs) is a rare genetic disorder of various age groups (infants, children, youth, or adult-onset) is characterized by progressive myoclonus, epileptic seizures and in most cases, dementia and ataxia. Death is the worst possible outcome.

Genetic research has led to the identification of many genes culprit, and others are expected to be found. PMEs including disease Unverricht-Lundborg (ULD), disease LaFora (LD), lipofuscinoses ceroid neuronal, sialidosis type I, epilepsy myoclonus and fiber red ragged (MERRF), Gaucher disease type 3, dentatorubral-pallidoluysian atrophy (DRPLA), and other rare forms of PMEs.

Monkeypox Virus Real Time PCR Kit

PDPS-AR064 1 unit Ask for price
Description: Creative Biogene Monkeypox Virus Real Time PCR Kit is used for the detection of monkeypox Virus in serum or lesion exudate samples by using real time PCR systems. Monkeypox virus (MPV) is a double-stranded DNA, zoonotic virus and a species of the genus Orthopoxvirus in the family Poxviridae. It is one of the human orthopoxviruses that includes variola (VARV), cowpox (CPX), and vaccinia (VACV) viruses. The kit contains a specific ready-to-use system for the detection of the monkeypox Virus. Fluorescence is emitted and measured by the real time systems' optical unit during the PCR.

Monkeypox Virus Real Time PCR Kit

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Description: The Bioperfectus Monkeypox Virus Real Time PCR Kit is an in vitro diagnostic test, based on real-time PCR technology, for the detection of DNA from the Monkeypox virus. Specimens can be obtained from human serum, lesion exudate samples and scab. BSL-2 facilities with standard BSL-2 work practices may be used for the test of t he Monkeypox virus.

Monkeypox Virus Real Time PCR Kit

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Description: Monkeypox virus is the virus that causes the disease monkeypox in both humans and animals. Monkeypox virus is an Orthopoxvirus, a genus of the family Poxviridae that contains other viral species that target mammals. The virus is mainly found in tropical rainforest regions of central and West Africa. The primary route of infection is thought to be contact with the infected animals or their bodily fluids. The genome is not segmented and contains a single molecule of linear double-stranded DNA, 185000 nucleotides long. The Monkeypox Virus real time PCR Kit contains a specific ready-to-use system for the detection of the Monkeypox Virusthrough polymerase chain reaction (PCR) in the real-time PCR system. The master contains reagents and enzymes for the specific amplification of the Monkeypox Virus DNA. Fluorescence is emitted and measured by the real time systems ́ optical unit during the PCR. The detection of amplified Monkeypox Virus DNA fragment is performed in fluorimeter channel 530nm with the fluorescent quencher BHQ1. DNA extraction buffer is available in the kit and serum or lesion exudate samples are used for the extraction of the DNA. In addition, the kit contains a system to identify possible PCR inhibition by measuring the 560nm fluorescence of the internal control (IC). An external positive control defined as 1×10^7 copies/ml is supplied which allow the determination of the gene load.

Monkeypox Virus Real Time PCR Kit

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Description: Monkeypox virus is the virus that causes the disease monkeypox in both humans and animals. Monkeypox virus is an Orthopoxvirus, a genus of the family Poxviridae that contains other viral species that target mammals. The virus is mainly found in tropical rainforest regions of central and West Africa. The primary route of infection is thought to be contact with the infected animals or their bodily fluids.The genome is not segmented and contains a single molecule of linear double-stranded DNA, 185000 nucleotides long.The Monkeypox Virus real time PCR Kit contains a specific ready-to-use system for the detection of the Monkeypox Virusthrough polymerase chain reaction (PCR) in the real-time PCR system. The master contains reagents and enzymes for the specific amplification of theMonkeypox VirusDNA. Fluorescence is emitted and measured by the real time systems ́ optical unit during the PCR. The detection of amplified Monkeypox Virus DNA fragment is performed in fluorimeter channelFAM with the fluorescent quencher BHQ1. DNA extraction buffer is available in the kit and serum or lesion exudate samples are used for the extraction of the DNA. In addition, the kit contains a system to identify possible PCR inhibition by measuring the HEX/VIC/JOE fluorescence of the internal control (IC). An external positive control defined as 1×107copies/ml is supplied which allow the determination of the gene load.

Human Real-time PCR DNA Quantitation after QPCR DNA Damage Analysis Kit

DD2H 1 Kit
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Mouse Real-time PCR DNA Quantitation after QPCR DNA Damage Analysis Kit

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Rat Real-time PCR DNA Quantitation after QPCR DNA Damage Analysis Kit

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Eztime Real - time PCRPremix 2x,Taqman

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Mouse DNA Damage Signaling Primer Library

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Mouse DNA Repair Primer Library I

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dsGreen for Real-Time PCR, 100×, 2 mL

61010 2 mL
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51010 1.5 mL
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41010 1 mL
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0.2ML CLEAR STRIP CAPS FOR REAL TIME PCR

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Azura PureView 250bp DNA Ladder - 100 Lanes

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PMA Real-Time PCR Bacterial Viability Kit - Salmonella enterica (invA)

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31034 1kit
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31035 1kit
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Novel Coronavirus COVID-19 (2019-nCoV) Real Time RT-PCR Kit

RR-0478-02 25 tests/kit
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Description: Novel Coronavirus (2019-nCoV) Real Time RT-PCR Kit is used for the qualitative detection of a novel coronavirus, which was identified in 2019 at Wuhan City, Hubei Province, China, in upper respiratory tract specimens (nasopharyngeal extracts, deep cough sputum, etc.) and lower respiratory tract specimens (alveoli irrigation fluid, etc.) by real time PCR systems.

Complete Bacterial Protein Extraction Reagent

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PMA Real-Time PCR Bacterial Viability Kit - E. coli O157:H7 (Z3276)

31037 1kit
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hsa-mir-521 Real-Time RT-PCR Detection and U6 Calibration Kit

20-abx097601
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Goat Brucellosis(Brucellosis) ELISA Kit

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qPCR plate-foil universal (for Real-time PCR, Light Cycler 480)

A26979 1x100 pcs
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Green Dye One Step qRT-PCR Master Mix For Quantitative Real Time PCR With ROX Dye

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PMA Real-Time PCR Bacterial Viability Kit - E. coli O157:H7 (Z3276) PMAxx

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AzuraQuant cDNA Synthesis Kit - 25 Reactions

AZ-1995 25 Reactions
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AzuraQuant cDNA Synthesis Kit - 100 Reactions

AZ-1996 100 Reactions
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0,1ML THIN WALL TUBES 8 PER STRIP. CLEAR & REAL TIME STRIP CAPS

PCR-0108-LP-RT-C 125/pk
EUR 850.8
Description: PCR Plates & Tubes; PCR Strip Tubes and Strip Caps - Axygen

0,1ML THIN WALL TUBES 8 PER STRIP. WHITE & REAL TIME STRIP CAPS

PCR-0108-LP-RT-W 125/pk
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Description: PCR Plates & Tubes; PCR Strip Tubes and Strip Caps - Axygen

Total Protein Extraction Kit: TM Buffer

K3011010-1 13 ml
EUR 194.4
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Exosomal DNA Extraction Kit

P230-25 - Ask for price

Exosomal DNA Extraction Kit

P230-50 - Ask for price

hsa-let-7a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097603
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hsa-let-7b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

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hsa-let-7c Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

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hsa-let-7d Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097606
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hsa-let-7e Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097607
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hsa-let-7f Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097608
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hsa-let-7g Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097609
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hsa-let-7i Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097610
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hsa-let-7f Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097611
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hsa-mir-1 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097612
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hsa-mir-7 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097613
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hsa-mir-9 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097614
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hsa-mir-9* Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097615
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hsa-mir-10a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097616
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hsa-mir-10b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097617
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hsa-mir-10a* Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097618
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hsa-mir-15a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

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hsa-mir-15b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097620
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hsa-mir-16 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097622
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hsa-mir-18a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097625
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hsa-mir-18b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

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hsa-mir-19a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

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hsa-mir-19b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

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hsa-mir-20a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

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hsa-mir-20b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

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hsa-mir-21 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097631
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hsa-mir-22 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

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hsa-mir-23a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097633
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hsa-mir-23b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097634
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hsa-mir-25 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

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hsa-mir-26a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

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hsa-mir-26b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097638
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  • 100 rxns
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  • 50 rxns

hsa-mir-27a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097639
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  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-27b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097640
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  • 100 rxns
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  • 50 rxns

hsa-mir-29a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097642
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  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-29b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097643
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  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-29c Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097644
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  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-30a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097645
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-30b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097647
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-30c Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097648
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-30d Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097650
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-30e Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097651
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-31 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097652
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-32 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097653
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-33a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097654
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-34a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097657
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-34b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097659
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-92a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097661
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-92b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097662
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-93 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097663
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-95 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097664
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-96 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097665
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-98 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097666
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-99a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097667
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-99b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097669
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-100 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097671
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-101 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097673
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-103 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097675
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-105 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097676
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-106a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097677
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-106b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097678
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-107 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097679
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-124 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097680
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-125a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097681
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-127 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097686
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-129 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097689
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-130a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097690
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-130b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097691
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-132 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097692
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-133a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097693
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-133b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097694
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-134 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097695
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-135b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097696
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-137 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097699
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-138 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097700
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-139 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097701
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-140 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097702
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-141 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097703
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-143 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097706
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-145 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097708
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-146a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097709
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-149 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097711
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-150 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097712
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-151 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097714
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

This article will review LaFora disease, autosomal recessive PME characterized by loud and photosensitive myoclonic seizures, drop attacks, ataxia, apraxia, cortical blindness, and rapidly progressive dementia. diagnosis requires the presence of pathognomic LaFora bodies (abnormal glycogen inclusions) in tissue biopsies in addition to the exclusion of other forms of PMEs.