Treatment with metformin in twelve patients with Lafora disease.

LaFora disease (LD) is a rare, lethal, progressive myoclonus epilepsy which no targeted therapies currently available. Studies in mouse models of LD showed a good response to metformin, a drug with neuroprotective effects famous.

For this reason, in 2016, the European Medicines Agency granted orphan designation for metformin for the treatment of LD. However, no clinical data available far.We retrospective data so collected in patients treated with metformin LD called three centres.Twelve Italy epilepsy patients with genetically confirmed LD (6 EPM2A, 6 NHLRC1) in the middle stage / final illness is treated with add -on metformin for an average period of 18 months (range: 6-36). Metformin titrated with average maintenance dose 1167 mg / day (range: 500-2000 mg). In four patients the dose is limited by gastrointestinal side effects.

No serious adverse events occurred. Three patients had a clinical response, which while two, characterized by a decrease in seizure frequency and a secure global clinical improvement.Metformin overall in our small cohort of patients with LD. Despite the poor clinical outcome, this may be associated with an advanced stage of the disease in our case and we can not exclude the role of metformin in slowing the progression of LD. Therefore, on the basis of preclinical data, we believe that treatment with metformin can be tried as early as possible in the course of LD.


LaFora disease (LD) is a rare autosomal recessive disorder characterized by progressive myoclonic epilepsy followed by neurological continuous decline, culminating in death within 10 years. LD leads to the accumulation of soluble, not normal, glycogen-like structures called LaFora body (LBS). It is caused by mutations in the gene encoding glycogen phosphatase (EPM2A) or E3 ubiquitin ligase master (EPM2B / NHLRC1).

Both proteins are involved in a complicated, however, not fully described pathway that regulates the metabolism of glycogen. EPM2A and complex formation master signal promoting protein ubiquitination participate in glycogen metabolism, in which mutations lead to the formation LBS dysfunctional.

 Treatment with metformin in twelve patients with Lafora disease.
Treatment with metformin in twelve patients with Lafora disease.

In vivo glutamate clearance defect in a mouse model LaFora disease.

LaFora disease (LD) is a neurodegenerative disorder that is rarely fatal characterized by epilepsy, neurodegeneration and accumulation of insoluble polyglucosan in the brain and other peripheral tissues. Although in the last two decades we have increased our knowledge on the molecular basis of the underlying pathophysiology of LD, only a small fraction of research on LD have paid attention to the mechanisms triggering one of the features of the most deadly of diseases: epilepsy.

Recent studies in our laboratory suggest that dysfunction in mouse activity astrocytic glutamate transporter 1 (GLT-1) may contribute to epilepsy in LD. In this work, we present a new in vivo evidence of dysfunction of GLT-1, contribute to increased extracellular glutamate levels in the hippocampus of a mouse model of disease LaFora (Epm2b – / -, lacking E3-ubiquitin ligase master). According to our results, Epm2b – / – mice showed increased neuronal activity, as assessed by expression of c-fos, in the hippocampus, an area directly related to epileptogenesis.

This brain area is presented lower ability to remove after a local synaptic glutamate GLT-1 blockade with dihydrokainate (DHK), compared with Epm2b + / + animals, indicating that these animals have permission glutamate compromised when the challenging conditions presented. These results correlated with upregulation of isoform minor hippocampus of GLT-1 gene, called GLT-1b, which has been associated with the compensation mechanism is activated in response to neuronal stress.

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

DLR-GOAT-Hu-96T 96T
EUR 725
Description: A sandwich quantitative ELISA assay kit for detection of Human Ghrelin-O-Acyltransferase (GOAT) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

RDR-GOAT-Hu-48Tests 48 Tests
EUR 589

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

RDR-GOAT-Hu-96Tests 96 Tests
EUR 820

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

RD-GOAT-Hu-48Tests 48 Tests
EUR 563

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

RD-GOAT-Hu-96Tests 96 Tests
EUR 783

Custom Antibody titration by ELISA up to 2 rabbits and 1 bleed

ELISA-1 1
EUR 202

ExoAb Antibody Kit (CD9, CD63, CD81, Hsp70 antibodies, rabbit anti-human) with goat anti-rabbit HRP secondary antibody

EXOAB-KIT-1 25 ul each
EUR 627

Frit Kit

FRIT-KIT 1each
EUR 124
Description: Kit to create frits in capillaries. Includes formamide, Kasil-1, Kasil-1624 and a cleaving tool.

Column Packing Kit

PACK-KIT 1pack
EUR 1035
Description: Column packing kit for pressure cells. Includes: HPREG regulator, TBNG10 tubing, CAP-75 capillary, and STRB5X2 stir bar.

PCR Mycoplasma Detection Kit

M034-Kit Kit
EUR 266

Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit

CAS400A-KIT 1 kit (10 rxn)
EUR 1110

CMV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV100PA-KIT 1 Kit
EUR 1132

CMV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV105PA-KIT 1 Kit
EUR 1132

MSCV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV120PA-KIT 1 Kit
EUR 1132

MSCV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV125PA-KIT 1 Kit
EUR 1132

Multiplex gRNA Kit + EF1-T7-hspCas9-H1-gRNA linearized SmartNuclease vector

CAS700A-KIT 10 rxn
EUR 1132

Multiplex gRNA Kit + CAG-T7-hspCas9-H1-gRNA linearized SmartNuclease vector

CAS720A-KIT 10 rxn
EUR 1132

Multiplex gRNA Kit + CMV-T7-hspCas9-H1-gRNA linearized SmartNuclease vector

CAS740A-KIT 10 rxn
EUR 1132

T7 gRNA SmartNuclease Synthesis Kit (includes CAS510A-1 & T7 IVT synthesis reagents)

CAS510A-KIT 1 Kit
EUR 805

Cas9 Nickase: CMV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV200PA-KIT 1 Kit
EUR 1132

Cas9 Nickase: CMV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV205PA-KIT 1 Kit
EUR 1132

Cas9 Nickase: MSCV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV220PA-KIT 1 Kit
EUR 1132

Cas9 Nickase: MSCV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV225PA-KIT 1 Kit
EUR 1132

Multiplex gRNA Kit + Cas9 Nickase: EF1-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector

CAS750A-KIT 10 rxn
EUR 1132

Multiplex gRNA Kit + Cas9 Nickase: CAG-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector

CAS770A-KIT 10 rxn
EUR 1132

Multiplex gRNA Kit + Cas9 Nickase: CMV-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector

CAS790A-KIT 10 rxn
EUR 1132

Cas9 SmartNuclease Extra Ligation Kit [includes 5x ligation buffer (10 ul) and Fast ligase (2.5ul)]

CAS9LIG-KIT 1 Kit
EUR 153

PinPoint-FC 293T Platform Kit for Targeted Gene Insertion (includes PIN320A-1, PIN200A-1, PIN510A-1 & PIN600A-1)

PIN320A-KIT 1 Kit
EUR 4941

PinPoint-FC Murine iPSC Platform Kit for Targeted Gene Insertion (includes PIN340iPS-1, PIN200A-1, PIN510A-1 & PIN600A-1)

PIN340iPS-KIT 1 Kit
EUR 4941

AAVS1 Safe Harbor Targeting Vector 2.0 - All-Purpose Donor (AAVS1-SA-puro-MCS), Complete Kit with CAS601A-1 (Cas9 SmartNuclease AAVS1-gRNA Targeting Vector) and GE640PR-1 (Junction PCR Primer Mix to confirm AAVS1 integration site)

GE620A-KIT 1 kit
EUR 2132

AAVS1 Safe Harbor Targeting Vector 2.0 - GOI Knock-in Donor (AAVS1-SA-puro-EF1-MCS), Complete Kit with CAS601A-1 (Cas9 SmartNuclease AAVS1-gRNA Targeting Vector) and GE640PR-1 (Junction PCR Primer Mix to confirm AAVS1 integration site)

GE622A-KIT 1 kit
EUR 2132

AAVS1 Safe Harbor Targeting Vector 2.0 - Reporter Knock-in Donor (AAVS1-SA-puro-MCS-GFP), Complete Kit with CAS601A-1 (Cas9 SmartNuclease AAVS1-gRNA Targeting Vector) and GE640PR-1 (Junction PCR Primer Mix to confirm AAVS1 integration site)

GE624A-KIT 1 kit
EUR 2132

Goat Brucella Antibody ELISA Kit 

abx364917-96tests 96 tests
EUR 637

Goat Antiphospholipid Antibody ELISA kit

E06A0830-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Antiphospholipid Antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Antiphospholipid Antibody ELISA kit

E06A0830-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Antiphospholipid Antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Antiphospholipid Antibody ELISA kit

E06A0830-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Antiphospholipid Antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Antiplatelet antibody ELISA kit

E06A0835-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Antiplatelet antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Antiplatelet antibody ELISA kit

E06A0835-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Antiplatelet antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Antiplatelet antibody ELISA kit

E06A0835-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Antiplatelet antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Sulfatide antibody ELISA kit

E06S0259-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Sulfatide antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Sulfatide antibody ELISA kit

E06S0259-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Sulfatide antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Sulfatide antibody ELISA kit

E06S0259-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Sulfatide antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Thrombopoietin antibody ELISA kit

E06T0057-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Thrombopoietin antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Thrombopoietin antibody ELISA kit

E06T0057-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Thrombopoietin antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Thrombopoietin antibody ELISA kit

E06T0057-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Thrombopoietin antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Thyroid antibody ELISA kit

E06T0498-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Goat Thyroid antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Thyroid antibody ELISA kit

E06T0498-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Goat Thyroid antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Thyroid antibody ELISA kit

E06T0498-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Goat Thyroid antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Trichinella antibody ELISA kit

E06T0543-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Trichinella antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Trichinella antibody ELISA kit

E06T0543-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Trichinella antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Trichinella antibody ELISA kit

E06T0543-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Trichinella antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Thyroglobulin Antibody ELISA kit

E06T0767-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Goat Thyroglobulin Antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Thyroglobulin Antibody ELISA kit

E06T0767-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Goat Thyroglobulin Antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Thyroglobulin Antibody ELISA kit

E06T0767-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Goat Thyroglobulin Antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Toxoplasma Antibody ELISA kit

E06T0880-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Goat Toxoplasma Antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Toxoplasma Antibody ELISA kit

E06T0880-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Goat Toxoplasma Antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Toxoplasma Antibody ELISA kit

E06T0880-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Goat Toxoplasma Antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Erythropoietin antibody ELISA kit

E06E0004-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Erythropoietin antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Erythropoietin antibody ELISA kit

E06E0004-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Erythropoietin antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Erythropoietin antibody ELISA kit

E06E0004-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Erythropoietin antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Endometrium antibody ELISA kit

E06E0147-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Endometrium antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Endometrium antibody ELISA kit

E06E0147-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Endometrium antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Endometrium antibody ELISA kit

E06E0147-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Endometrium antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Endostatin antibody ELISA kit

E06E0174-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Endostatin antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Endostatin antibody ELISA kit

E06E0174-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Endostatin antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Endostatin antibody ELISA kit

E06E0174-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Endostatin antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Elastin antibody ELISA kit

E06E0293-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Elastin antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Elastin antibody ELISA kit

E06E0293-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Elastin antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Elastin antibody ELISA kit

E06E0293-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Elastin antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Cysticercosis antibody ELISA kit

E06C0871-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Cysticercosis antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Cysticercosis antibody ELISA kit

E06C0871-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Cysticercosis antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Cysticercosis antibody ELISA kit

E06C0871-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Cysticercosis antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Leptin Antibody ELISA kit

E06L0039-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Leptin Antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Leptin Antibody ELISA kit

E06L0039-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Leptin Antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Leptin Antibody ELISA kit

E06L0039-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Leptin Antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Melanocyte antibody ELISA kit

E06M0242-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Melanocyte antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Melanocyte antibody ELISA kit

E06M0242-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Melanocyte antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Melanocyte antibody ELISA kit

E06M0242-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Melanocyte antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

vWF Acty. Kit

ABP-ACT-KIT 12 x 8 microwells
EUR 428

vWF Ant. Kit

ABP-TOT-KIT 12 x 8 microwells
EUR 394

hspCas9 AAVS1 Safe Harbor Knock-in Donor (AAVS1-SA-puro-EF1-hspCas9)

CAS620A-KIT 1 kit
EUR 2152
Description: Complete Kit with CAS601A-1 (Cas9 SmartNuclease AAVS1-gRNA Targeting Vector), CAS640PR-1 (Junction PCR Primer Mix to confirm Cas9 integration site), and CAS9-PR-1 (PCR primers to confirm Cas9 expression)

PinPoint-FC System for Platform Cell Line Generation & Retargeting (includes PIN300A-1, FC200PA-1, PIN200A-1, PIN510A-1, & PIN600A-1)

PIN300A-KIT 1 Kit
EUR 2798

PinPoint-HR System for Platform Cell Line Generation & Retargeting (includes PIN400A-1, PIN200A-1, PIN510A-1, & PIN600A-1)

PIN400A-KIT 1 Kit
EUR 2798

PinPoint-HR System for Platform Cell Line Generation & Retargeting of AAVS1 Safe Harbor Locus (includes PIN410A-1, GE601A-1, PIN200A-1, PIN510A-1, & PIN600A-1)

PIN410A-KIT 1 Kit
EUR 4335

PinPoint-HR System for Platform Cell Line Generation & Retargeting of AAVS1 Safe Harbor Locus (includes PIN410A-1, CAS601A-1, PIN200A-1, PIN510A-1, & PIN600A-1)

PIN412A-KIT 1 Kit
EUR 4335

PrecisionX Multiplex gRNA Cloning Kit

CAS9-GRNA-KIT 10 rxn
EUR 445

mRNAExpress mRNA Synthesis kit (5 reactions)

MR-KIT-1 5 reactions
EUR 1152

ELISA kit for Goat Parvovirus Antibody  Kit

KTE50035-48T 48T
EUR 354
Description: Quantitative sandwich ELISA for measuring Goat Parvovirus Antibody  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Goat Parvovirus Antibody  Kit

KTE50035-5platesof96wells 5 plates of 96 wells
EUR 2252
Description: Quantitative sandwich ELISA for measuring Goat Parvovirus Antibody  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Goat Parvovirus Antibody  Kit

KTE50035-96T 96T
EUR 572
Description: Quantitative sandwich ELISA for measuring Goat Parvovirus Antibody  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Goat Circovirus Antibody  Kit

KTE50048-48T 48T
EUR 354
Description: Quantitative sandwich ELISA for measuring Goat Circovirus Antibody  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Goat Circovirus Antibody  Kit

KTE50048-5platesof96wells 5 plates of 96 wells
EUR 2252
Description: Quantitative sandwich ELISA for measuring Goat Circovirus Antibody  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Goat Circovirus Antibody  Kit

KTE50048-96T 96T
EUR 572
Description: Quantitative sandwich ELISA for measuring Goat Circovirus Antibody  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Goat Brucella Antibody

KTE50037-48T 48T
EUR 354
Description: Quantitative sandwich ELISA for measuring Goat Brucella Antibody in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Goat Brucella Antibody

KTE50037-5platesof96wells 5 plates of 96 wells
EUR 2252
Description: Quantitative sandwich ELISA for measuring Goat Brucella Antibody in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Goat Brucella Antibody

KTE50037-96T 96T
EUR 572
Description: Quantitative sandwich ELISA for measuring Goat Brucella Antibody in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

In conclusion, the hippocampus of Epm2b – / – mice presents an in vivo decrease in glutamate uptake that may contribute to epileptogenesis.